Well??defined NHC Pd complex??mediated intermolecular direct annulations for synthesis of functionalized indoles (NHC= N??hetero??cyclic carbene)

…, SX Guo, LL Qiu, GP Wu, JX Fang

Index: Jin, Zhong; Guo, Su-Xian; Qiu, Ling-Ling; Wu, Gui-Ping; Fang, Jian-Xin Applied Organometallic Chemistry, 2011 , vol. 25, # 7 p. 502 - 507

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Citation Number: 7

Abstract

Abstract As alternatives to the common tertiary phosphine/Pd systems, well-defined N- heterocyclic carbene–Pd complexes have been proven to be highly efficient precatalysts for intermolecular direct annalution of o-haloanilines and ketones at lower catalyst loadings. A highly efficient and practical protocol for synthesis of functionalized indoles was developed using (IPr) Pd (acac) Cl as catalyst. Both o-bromoanilines and o-chloroanilines gave rise ...

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