N, N-Disubstituted 6-alkoxy-2-pyridinamines as anticonvulsant agents

MR Pavia, CP Taylor, FM Hershenson…

Index: Pavia, Michael R.; Taylor, Charles P.; Hershenson, Fred M.; Lobbestael, Sandra J. Journal of Medicinal Chemistry, 1987 , vol. 30, # 7 p. 1210 - 1214

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Citation Number: 25

Abstract

1212 Journal of Medicinal Chemistry, 1987, Vol. 30, No. 7 starting material was commercially available 2, 6-dichloropyridine. Reaction of a sodium alkoxide (prepared from the appropriate alcohol and sodium metal) with 2, 6-dichloropyridine affords the 2-alkoxy-6- chloropyridine. After purification, this material was reacted with 2 molar equiv of the N, N- disubstituted amino compound in 1-butanol to give the desired derivatives.