Journal of Separation Science 2008-07-01

Enantioseparation of kavain on Chiralpak IA under normal-phase, polar organic and reversed-phase conditions.

Roberto Cirilli, Rosella Ferretti, Bruno Gallinella, Anna Rita Bilia, Franco Francesco Vincieri, Francesco La Torre

Index: J. Sep. Sci. 31(12) , 2206-10, (2008)

Full Text: HTML

Abstract

First baseline HPLC enantioseparation of kavain is described. Complete enantiodiscrimination was achieved on the immobilised-type Chiralpak IA chiral stationary phase (CSP) using pure methanol and simple methanol-water and ethanol-water mixtures as eluents. A water-dependent enantioselectivity was clearly demonstrated. Performance of the Chiralpak IA CSP in polar organic and RP conditions was compared with that of five coated polysaccharide-derived CSPs used in normal-phase mode.

Related Compounds

  • Kavain

Related Articles:

Fatal kavalactone intoxication by suicidal intravenous injection.

2015-04-01

[Forensic Sci. Int. 249 , e7-11, (2015)]

Kavalactones fail to inhibit alcohol dehydrogenase in vitro.

2006-02-01

[Phytomedicine 13(3) , 192-5, (2006)]

Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.

2011-03-01

[Phytother Res. 25(3) , 417-23, (2011)]

Permeability studies of Kavalactones using a Caco-2 cell monolayer model.

2007-06-01

[J. Clin. Pharm. Ther. 32(3) , 233-9, (2007)]

Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.

2005-01-01

[Phytochem. Anal. 16(3) , 217-21, (2005)]

More Articles...