Journal of Agricultural and Food Chemistry 1999-06-01

Metabolism of [(14)C]flusilazole in the goat.

J J Anderson, L M Shalaby, D S Berg

Index: J. Agric. Food Chem. 47(6) , 2439-46, (1999)

Full Text: HTML

Abstract

[Phenyl(U)-(14)C] and [triazole(3)-(14)C]flusilazole ([(bis 4-fluorophenyl)]methyl(1H-1,2,4-triazole-1-ylmethyl)silane; I) were extensively metabolized when fed to lactating goats (Capra hircus). The primary metabolites identified in goat tissues and milk were bis(4-fluorophenyl)(methyl)silanol (II) and 1H-1,2,4-triazole (III). Concentrations of total radiolabeled residues in the milk ranged from 0.09 to 0.74 microg/mL. Concentrations of radiolabeled residues found in tissues when the [(14)C] label was in the phenyl or triazole position, respectively, were 13.5 and 3.54 microg/g (liver), 8.74 and 0.75 microg/g (kidney), 0.41 and 0.52 microg/g (leg muscle), and 4.07 and 0.94 microg/g (back fat). Urine contained an additional major metabolite identified as [bis(4-fluorophenyl)](methyl)silylmethanol (IV) and its glucuronic acid conjugate (V). With either labeled form of flusilazole, the majority of the recovered radiolabel was excreted in urine or feces.

Related Compounds

  • Flusilazole

Related Articles:

Real-time 2D separation by LC × differential ion mobility hyphenated to mass spectrometry.

2012-03-01

[Anal. Bioanal. Chem 402(8) , 2555-64, (2012)]

Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.).

2006-01-01

[Commun. Agric. Appl. Biol. Sci. 71(3 Pt B) , 1041-8, (2006)]

Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure.

2012-05-01

[Toxicol. Sci. 127(1) , 303-12, (2012)]

Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures.

2011-03-01

[Toxicol. Appl. Pharmacol. 251(2) , 110-8, (2011)]

Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn).

2012-08-01

[Toxicol. Appl. Pharmacol. 262(3) , 330-40, (2012)]

More Articles...