Synthesis and structure-activity studies of novel orally active non-terpenoic 2, 3-oxidosqualene cyclase inhibitors

H Dehmlow, JD Aebi, S Jolidon, YH Ji…

Index: Journal of Medicinal Chemistry, , vol. 46, # 15 p. 3354 - 3370

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Citation Number: 56

Abstract

... Journal of Medicinal ... Further skeletal rearrangements through 1,2-shifts of hydride and methyl substituents yield lanosterol. The first compounds that represented a starting point for medicinal chemistry were found in the chemical collection of a fungicide project. ... Chemistry. ...

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