Nucleosides, Nucleotides & Nucleic Acids 2006-01-01

Simple synthesis and anti-HIV activity of novel 3'-vinyl branched apiosyl pyrimidine nucleosides.

Chang Hyun Oh, Jin Woo Kim, Joon Hee Hong

Index: Nucleosides Nucleotides Nucleic Acids 25(8) , 871-8, (2006)

Full Text: HTML

Abstract

Novel vinyl branched apiosyl nucleosides were synthesized in this study. Apiosyl sugar moiety was constructed by sequential ozonolysis and reductions. The bases (uracil and thymine) were efficiently coupled by glycosyl condensation procedure (persilyated base and TMSOTf). The antiviral activities of the synthesized compounds were evaluated against the HIV-1, HSV-1, HSV-2, and HCMV. Compound 10beta displayed moderate anti-HIV activity (EC50 = 17.3 microg/mL) without exhibiting any cytotoxicity up to 100 microM.

Related Compounds

  • D-apiose

Related Articles:

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

2015-06-17

[J. Agric. Food Chem. 63 , 5670-81, (2015)]

Synthesis of apiose-containing oligosaccharide fragments of the plant cell wall: fragments of rhamnogalacturonan-II side chains A and B, and apiogalacturonan.

2011-10-07

[Org. Biomol. Chem. 9(19) , 6670-84, (2011)]

The acetylation of apiitol in the determination of apiose.

1990-05-15

[Carbohydr. Res. 199(1) , 55-65, (1990)]

cDNA-AFLP analysis on bolting or flowering of flowering Chinese cabbage and molecular characteristics of BrcuDFR-like/BrcuAXS gene.

2012-07-01

[Mol. Biol. Rep. 39(7) , 7525-31, (2012)]

Synthesis and in vitro activity of 4' and 5'-modified analogues of apiosyl nucleosides as potent anti-HCV agents.

2009-11-01

[Nucleosides Nucleotides Nucleic Acids 28(11) , 1104-16, (2009)]

More Articles...