Rapid Communications in Mass Spectrometry 2006-01-01

Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry.

Kannan Vivekanandan, Madugundu Guru Swamy, Sudhanand Prasad, Rama Mukherjee, Anand C Burman

Index: Rapid Commun. Mass Spectrom. 20(11) , 1731-5, (2006)

Full Text: HTML

Abstract

A strategy is developed for the identification of isocephalomannine in the presence of alkali metal ion adducts and other cephalomannine isomers in a paclitaxel active pharmaceutical ingredient. Intact molecular ion analyses and a sub-structural study have been performed for the differentiation of isocephalomannine (2-debenzoylpaclitaxel-2-pentenoate) from cephalomannine and 7-epi-cephalomannine. A comparative study of the cephalomannine isomers was carried out using molecular ions (MS) and fragmentation patterns (MS/MS) for sub-structural analysis. An attempt has been made to identify isocephalomannine in Cremophor(R) EL formulations.Copyright (c) 2006 John Wiley & Sons, Ltd.

Related Compounds

  • Cephalomannine

Related Articles:

Determination of paclitaxel and related taxanes in bulk drug and injectable dosage forms by reversed phase liquid chromatography.

1997-06-01

[Anal. Chem. 69(11) , 2008-16, (1997)]

Determination of cephalomannine in rat plasma by gradient elution UPLC-MS/MS method.

2014-07-15

[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 963 , 70-4, (2014)]

Microbial transformation of cephalomannine by Luteibacter sp.

2007-12-01

[J. Nat. Prod. 70(12) , 1846-9, (2007)]

Seasonal changes in the concentrations of four taxoids in Taxus baccata L. during the autumn-spring period.

1999-05-01

[Phytomedicine 6(2) , 135-40, (1999)]

Rapid separation of four main taxoids in Taxus species by a combined LLP-SPE-HPLC (PAD) procedure.

2006-06-01

[J. Sep. Sci. 29(9) , 1237-44, (2006)]

More Articles...