Bioorganic & Medicinal Chemistry Letters 2003-01-06

Hepatoprotective pyrrole derivatives of Lycium chinense fruits.

Young-Won Chin, Song-Won Lim, Seok-Ho Kim, Dong-Yun Shin, Young-Ger Suh, Yang-Bae Kim, Young Choong Kim, Jinwoong Kim

Index: Bioorg. Med. Chem. Lett. 13(1) , 79-81, (2003)

Full Text: HTML

Abstract

As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4 and 65.8%, respectively).

Related Compounds

  • Methyl 4-Iodobuta...

Related Articles:

Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA.

2009-02-21

[Org. Biomol. Chem. 7(4) , 635-8, (2009)]

IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone. Himly M, et al.

[J. Allergy Clin. Immunol. 111(4) , 882-88, (2003)]

More Articles...