International Journal of Antimicrobial Agents 2001-09-01

Role of sultamicillin and ampicillin/sulbactam in the treatment of upper and lower bacterial respiratory tract infections.

H Lode

Index: Int. J. Antimicrob. Agents 18(3) , 199-209, (2001)

Full Text: HTML

Abstract

The emergence of beta-lactamase-mediated resistance to beta-lactam antibiotics among key respiratory tract pathogens has threatened the usefulness of the beta-lactam agents familiar to physicians as being clinically effective and well tolerated. This article reassesses the clinical usefulness of ampicillin when administered in combination with the beta-lactamase inhibitor sulbactam, either intravenously or orally (as the mutual prodrug sultamicillin), in the treatment of upper and lower respiratory tract infections. Numerous clinical studies and several meta-analyses indicate that ampicillin/sulbactam and sultamicillin are clinically effective and well tolerated in both adults and children, in agreement with published North American and European guidelines.

Related Compounds

  • Ampicillin
  • Sulbactam
  • Sultamicillin

Related Articles:

Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein.

2015-04-01

[J. Virol. 89(8) , 4421-33, (2015)]

BBS4 directly affects proliferation and differentiation of adipocytes.

2014-09-01

[Cell. Mol. Life Sci. 71(17) , 3381-92, (2014)]

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.

2015-02-17

[Proc. Natl. Acad. Sci. U. S. A. 112(7) , E747-56, (2015)]

Membrane anchor of cytochrome P450 reductase suppresses the uncoupling of cytochrome P450.

2015-01-01

[Chem. Pharm. Bull. 63(4) , 286-94, (2015)]

Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.

2015-02-01

[PLoS Pathog. 11(2) , e1004645, (2015)]

More Articles...