Toxicology Letters 1983-07-01

Autoradiography in mice of tritiated 2-(2-furyl)benzimidazole and melanin-binding in vitro.

A Frank, B Larsson, S Fabiansson

Index: Toxicol. Lett. 17(3-4) , 267-73, (1983)

Full Text: HTML

Abstract

The distribution of tritiated 2-(2-furyl)benzimidazole ([3H]FB) in male and pregnant albino mice and male pigmented mice was studied by whole-body autoradiography. The most notable finding was the accumulation of radioactivity in the melanin-containing tissues of the eye, the inner ear and the hair follicles. An additional study in vitro on isolated bovine-eye melanin showed a substantial binding of [3H]FB to the melanin. The general distribution was characterized by a rapid excretion pattern, except for uptake in the thyroid and nasal mucosa. Transfer to fetuses was significant and the fetal distribution was dominated by excretion.

Related Compounds

  • Fuberidazole

Related Articles:

Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors.

2010-07-15

[Bioorg. Med. Chem. Lett. 20 , 4038-44, (2010)]

Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions.

2006-01-26

[J. Med. Chem. 49 , 511-22, (2006)]

Quantitative Fusarium spp. and Microdochium spp. PCR assays to evaluate seed treatments for the control of Fusarium seedling blight of wheat.

2007-06-01

[J. Appl. Microbiol. 102(6) , 1645-53, (2007)]

Possible bitertanol and fuberidazole poisoning in young pheasants.

2001-07-28

[Vet. Rec. 149(4) , 118-20, (2001)]

Determination of benzimidazolic fungicides in fruits and vegetables by supramolecular solvent-based microextraction/liquid chromatography/fluorescence detection.

2009-09-21

[Anal. Chim. Acta 650(2) , 207-13, (2009)]

More Articles...