Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines

RM Kanojia, JJ Salata, J Kauffman

Index: Kanojia, Ramesh M.; Salata, Joseph J.; Kauffman, Jack Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2819 - 2823

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Citation Number: 2

Abstract

The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1- aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC20 of 3 nM, ranks as one of the most potent (in vitro) compounds reported.