Methylglyoxal bis (guanylhydrazone) analogs: multifunctional inhibitors for polyamine enzymes

K Nakashima, H Hibasami, T Tsukada…

Index: Nakashima, Kunio; Hibasami, Hiroshige; Tsukada, Tetsuya; Maekawa, Satoru European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 553 - 558

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Citation Number: 11

Abstract

Abstract Methylglyoxal bis (3-aminopropyl-amidinohydrazone)(MGBA), methylglyoxal bis (4- aminobutyl-amidinohydrazone)(MGBT), methylglyoxal bis (cyclohexyl-amidinohydrazone)( MGBC) and methylglyoxal bis (butyl-amidinohydrazone)(MGBB) were synthesized as potent competitive inhibitors for polyamine biosynthetic enzymes. Four compounds competitively inhibited S-adenosylmethionine decarboxylase. Ornithine decarboxylase was also ...