Journal of Applied Toxicology 1985-12-01

Toxicity of aromatic disulphides. II. Intraerythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides.

R Munday

Index: J. Appl. Toxicol. 5(6) , 409-13, (1985)

Full Text: HTML

Abstract

Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro. It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of non-protein and protein-bound thiols) in these cells. Such changes were also recorded in erythrocytes exposed to 4,4'-diaminodiphenyl disulphide, 2,2'-diaminodiphenyl disulphide, 4,4'-dimethyldiphenyl disulphide, 4,4'-dinitrodiphenyl disulphide, diphenyl disulphide-2,2'-dicarboxylic acid and dibenzyl disulphide. The relative potency of these compounds in causing erythrocyte damage is correlated with their ability to generate 'active oxygen' species in vitro.

Related Compounds

  • 4,4'-Thiodianiline

Related Articles:

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

2009-09-01

[Eur. J. Med. Chem. 44 , 3658-64, (2009)]

In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.

2009-09-01

[Bioorg. Med. Chem. Lett. 19 , 5012-5, (2009)]

DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens.

2005-03-01

[Toxicol. Appl. Pharmacol. 203(2) , 99-105, (2005)]

4,4'-Thiodianiline.

1982-04-01

[IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 27 , 147-54, (1982)]

4,4'-Thiodianiline.

2011-01-01

[Rep. Carcinog. 12 , 404-5, (2011)]

More Articles...