Synthesis of 3, 4??Dihydroisoquinolin??1??ones from N??Boc??(β??Arylethyl) carbamates via Isocyanate Intermediates

…, S Hwang, C Kim, JH Seo, S Kim

Index: In, Jinkyung; Hwang, Soonho; Kim, Changhun; Seo, Jae Hong; Kim, Sanghee European Journal of Organic Chemistry, 2013 , # 5 p. 965 - 971

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Citation Number: 4

Abstract

Abstract Mild reaction conditions for the regioselective synthesis of isoquinolin-1-ones and related fused-ring heterocycles from N-Boc-protected (β-arylethyl) carbamates are described. The reactions involved the use of Tf 2 O and 2-chloropyridine and isocyanates are likely to be key intermediates. The method was extended to substrates bearing less nucleophilic aryl moieties by using Lewis acid additives, such as BF 3· Et 2 O, to enhance ...

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