Sonogashira cross-coupling reaction in 4-chloro-2-trichloromethylquinazoline series is possible despite a side dimerization reaction
C Kieffer, P Verhaeghe, N Primas, C Castera-Ducros…
Index: Kieffer, Charline; Verhaeghe, Pierre; Primas, Nicolas; Castera-Ducros, Caroline; Gellis, Armand; Rosas, Roselyne; Rault, Sylvain; Rathelot, Pascal; Vanelle, Patrice Tetrahedron, 2013 , vol. 69, # 14 p. 2987 - 2995
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Citation Number: 14
Abstract
We studied the Sonogashira coupling reaction between 4-chloro-2- trichloromethylquinazoline and various terminal alkynes, mainly in phenylacetylene series. A brief review of the literature shows that mono-or polybromo/chloromethylated substrates, especially in aromatic series, are very rarely compatible with the achievement of Sonogashira reactions. Thus, although the 4-chloroquinazoline scaffold is a very good ...