Drug Development and Industrial Pharmacy 1998-03-01

Study of standard tablet formulation based on fluidized-bed granulation.

H Sunada, M Hasegawa, T Makino, H Sakamoto, K Fujita, T Tanino, H Kokubo, T Kawaguchi

Index: Drug Dev. Ind. Pharm. 24(3) , 225-33, (1998)

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Abstract

In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation.

Related Compounds

  • 2-Ethoxybenzamide

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