Fmoc-based solid-phase peptide synthesis using a new t-alcohol type 4-(1′, 1′-dimethyl-1′-hydroxypropyl) phenoxyacetyl handle (DHPP)–resin (Fmoc= fluoren-9- …

K Akaji, Y Kiso, LA Carpino

Index: Akaji, Kenichi; Kiso, Yoshiaki; Carpino, Louis A. Journal of the Chemical Society, Chemical Communications, 1990 , # 7 p. 584 - 586

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Citation Number: 14

Abstract

The loss of C-terminal dipeptide through diketopiperazine formation during Fmoc-based solid-phase peptide synthesis has been effectively suppressed by anchoring the first Fmoc amino acid chloride to a new 4-(1′, 1′-dimethyl-1′-hydroxypropyl) phenoxyacetyl handle (DHPP)-resin; this new t-alcohol type DHPP–resin has been successfully applied to the solid- phase synthesis of bradykinin potentiator B (an eleven-rersidue peptide)(Fmoc= fluoren-9- ...