Tyrosine kinase inhibitors. 6. Structure-activity relationships among N-and 3-substituted 2, 2'-diselenobis (1 H-indoles) for inhibition of protein tyrosine kinases and …

…, CD Wolfangel, LA Ambroso, WL Elliott…

Index: Showalter, H. D. Hollis; Sercel, Anthony D.; Leja, Boguslawa M.; Wolfangel, Craig D.; Ambroso, Linda A.; Elliott, William L.; Fry, David W.; Kraker, Alan J.; Howard, Curtis T.; Lu, Gina H.; Moore, Charles W.; Nelson, James M.; Roberts, Bill J.; Vincent, Patrick W.; Denny, William A.; Thompson, Andrew M. Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 413 - 426

Full Text: HTML

Citation Number: 73

Abstract

A small series of 2, 2'-diselenobis (1 H-indoles) was synthesized as redox-modified congeners of our earlier reported 2, 2'-dithiobis (1 H-indole) series. Utilizing chemistry similar to that developed earlier for the disulfur series, compounds were made from 2- halogeno-3-indolecarboxylic acid precursors bearing various polar functionality at the C-3 position and small alkyl substituents at the N-1 position of the indole nucleus. Additional ...