Chemistry Letters

Synthesis and physical nature of fluorescent photoaffinity probe for the bioorganic studies on tautomycin, a protein phosphatase type 1 selective inhibitor

M Kurono, M Isobe

Index: Kurono, Masakuni; Isobe, Minoru Chemistry Letters, 2004 , vol. 33, # 4 p. 452 - 453

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Citation Number: 8

Abstract

Fluorescent photoaffinity probe, which possesses a dansyl amide functional group on the maleic moiety of tautomycin, was prepared in order to detect the trace amount of labeled peptides. The parent compound dramatically showed fluorescence quenching before the photoreaction due to the exciplex formation on the basis of the folded conformation. Several benzhydrol analogs, on the other hand, recovered the strong fluorescence; thus, this ...

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