Molecules 2007-01-01

Salicylanilide acetates: synthesis and antibacterial evaluation.

Jarmila Vinsova, Ales Imramovsky, Vladimir Buchta, Martina Ceckova, Martin Dolezal, Frantisek Staud, Josef Jampilek, Jarmila Kaustova

Index: Molecules 12(1) , 1-12, (2007)

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Abstract

A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential and their in vitro activity against drug resistant and sensitive clinical isolates of Mycobacteria were found to be equivalent or better than a standard of isoniazide, a well-known first-line drug for tuberculosis treatment.

Related Compounds

  • Salicylanilide

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