Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents

T Shinozuka, K Shimada, S Matsui, T Yamane…

Index: Bioorganic and Medicinal Chemistry, , vol. 14, # 20 p. 6807 - 6819

Full Text: HTML

Citation Number: 9

Abstract

... Bioorganic & Medicinal Chemistry. ... a Medicinal Chemistry Research Laboratories, Sankyo Co ... Cathepsin K is an attractive pharmaceutical target for the treatment of osteoporosis as its primary role is the degradation of type I collagen, one of the main constituents of bone matrix. ...

Related Articles:

Design and synthesis of 3, 7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 4 p. 909 - 912]

Studies on 1, 3-benzoxazines. I. Synthesis of primary 2-amino-pyridines via the reaction of imidoyl chlorides of 1, 3-benzoxazines with pyridine N-oxides.

[Chemical and Pharmaceutical Bulletin, , vol. 28, # 2 p. 465 - 472]

A general and efficient 2-amination of pyridines and quinolines

[Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557]

Design and synthesis of 3, 7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR

[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 4 p. 909 - 912]

More Articles...