Efficient total syntheses of louisianins C and D

CY Chang, HM Liu, RT Hsu

Index: Chang, Ching-Yao; Liu, Hui-Ming; Hsu, Ru-Ting Tetrahedron, 2009 , vol. 65, # 4 p. 748 - 751

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Citation Number: 6

Abstract

An efficient synthetic route for the preparation of louisianins C and D was developed starting with the commercially available 4-cyanopyridine. Louisianins C and D were synthesized in seven steps and with overall yields 22% and 20%, respectively, following a novel cyclization– decarboxylation sequence involving 4-bromo-6, 7-dihydrocyclopenta [c] pyridin-5-one as the key intermediate.