Potential Carcinolytic Agents. 1, 2 V. Enamine Mustards

ZB Papanastassiou, RJ Bruni…

Index: Papanastassiou,Z.B. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 701 - 706

Full Text: HTML

Citation Number: 17

Abstract

Recezved February 10, 1967 ii number of enamine must, ards of the general formula ZCH= C (R) N (CH2CH2X) 2, where Z and R are electronwithdrawing groups or R may be H, arid X is C1, F, or OS02CH3, have been synthesized as possible antitumor ageiits. These compounds, all deactivated alkylating ageiits because the electron-withdrawing group (s) decrease t, he basicity of the riitrogen, were expected to be sensitive to acid hydrolysis ...