The Baylis–Hillman approach to quinoline derivatives

OB Familoni, PJ Klaas, KA Lobb, VE Pakade…

Index: Familoni, Oluwole B.; Klaas, Phindile J.; Lobb, Kevin A.; Pakade, Vusumzi E.; Kaye, Perry T. Organic and Biomolecular Chemistry, 2006 , vol. 4, # 21 p. 3960 - 3965

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Citation Number: 35

Abstract

Baylis–Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo-and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed.

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