Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2013-01-15

Sodium oxybate intolerance associated with familial serum acylcarnitine elevation.

Jon Berner

Index: J. Clin. Sleep Med. 9(1) , 71-2, (2013)

Full Text: HTML

Abstract

Our case describes clinical features of two families defined by joint phenotypes: sodium oxybate intolerance and elevated serum acylcarnitines. Oxybate intolerance variably presents as either cervical dystonia or sleep-related eating disorder. Our objective is to identify biological markers which predict a poor response to sodium oxybate as a treatment for disturbed sleep. Familial inheritance pattern, genotype analysis, multiorgan system involvement, and response to treatment suggest the presence of a secondary cause of fatty oxidation defect, i.e., mitochondrial disorder. Our case report supports the possible conclusion that variance in human mitochondrial metabolism may affect sodium oxybate tolerability.

Related Compounds

  • 4-Hydroxybutanoic...

Related Articles:

An improved design of water-soluble propofol prodrugs characterized by rapid onset of action.

2014-04-01

[Anesth. Analg. 118(4) , 745-54, (2014)]

Treatment of alcohol dependence: recent progress and reduction of consumption.

2014-12-01

[Minerva Med. 105(6) , 447-66, (2014)]

Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.

2013-03-01

[J. Pharmacol. Exp. Ther. 344(3) , 553-60, (2013)]

Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone.

2013-04-01

[J. Pharmacol. Exp. Ther. 345(1) , 102-10, (2013)]

The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol.

2012-07-01

[Clin. Toxicol. (Phila.) 50(6) , 458-70, (2012)]

More Articles...