A large-scale synthesis of enantiomerically pure cetirizine dihydrochloride using preparative chiral HPLC

DA Pflum, HS Wilkinson, GJ Tanoury…

Index: Organic Process Research and Development, , vol. 5, # 2 p. 110 - 115

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Citation Number: 26

Abstract

... Organic Process Research & Development. ... Cetirizine exists as a free base at pH between 7 and 9; however, the partitioning coefficient between water and any practical process solvent is less than 1 and would ... These results led us to turn to a lengthier hydrolysis procedure. ...