Synthesis and in vitro and in vivo evaluation of SiFA-tagged bombesin and RGD peptides as tumor imaging probes for positron emission tomography

S Lindner, C Michler, S Leidner, C Rensch…

Index: Lindner, Simon; Michler, Christina; Leidner, Stephanie; Rensch, Christian; Waengler, Carmen; Schirrmacher, Ralf; Bartenstein, Peter; Waengler, Bjoern Bioconjugate Chemistry, 2014 , vol. 25, # 4 p. 738 - 749

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Citation Number: 17

Abstract

Gastrin-releasing-peptide (GRP)-receptors and αvβ3-integrins are widely discussed as potential target structures for oncological imaging with positron emission tomography (PET). Favored by the overexpression of receptors on the surface of tumor cells good imaging characteristics can be achieved with highly specific radiolabeled receptor ligands. PEGylated bombesin (PESIN) derivatives as specific GRP receptor ligands and RGD (one ...