Creating Structural Manifolds from a Common Precursor: Basicity Gradient??Driven Isomerization of Halopyridines

M Schlosser, C Bobbio

Index: Schlosser, Manfred; Bobbio, Carla European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180

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Citation Number: 5

Abstract

Abstract 5-Chloro-2, 3-difluoropyridine, an intermediate in the manufacturing process of an industrial pesticide, can be hydrolyzed to 5-chloro-3-fluoro-2H-pyridinone and the latter converted into 2, 5-dichloro-3-fluoropyridine (1a), 2-bromo-5-chloro-3-fluoropyridine (1b), 5- chloro-3-fluoro-2-iodopyridine (1c) and 3-chloro-5-fluoropyridine (1d). Consecutive treatment of these four substrates with lithium diisopropylamide and carbon dioxide or ...