Synthesis of 5'-carboxy-N'-nitrosonornicotine and 5'-[14C] carboxy-N'-nitrosonornicotine

A Abbaspour, SS Hecht…

Index: Abbaspour, Aziz; Hecht, Stephen S.; Hoffmann, Dietrich Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3474 - 3477

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Citation Number: 10

Abstract

Exploration of this concept required synthesis of labeled and unlabeled 2 for metabolism studies and bioassays in experimental animals. One previous synthesis of 2 has been reported, but this was not suitable for preparation of the labeled compound. sp6 In this paper we describe a new synthesis of 2 and its application to the preparation of [carbo~ y-'~ C] 2.