Xenobiotica 1985-06-01

4,5-Dimethylthiazole-N-oxide-S-oxide: a metabolite of chlormethiazole in man.

C P Offen, M J Frearson, K Wilson, D Burnett

Index: Xenobiotica 15(6) , 503-11, (1985)

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Abstract

The metabolic fate of chlormethiazole in healthy male subjects has been investigated following the oral administration of a single dose of chlormethiazole edisylate. Five urinary C-oxidation metabolites were identified and shown to be identical with previously reported metabolites. A novel metabolite, of molecular formula C5H7NO2S, was shown by trimethylsilylation, deuterium exchange, reduction studies and by its i.r., n.m.r. and mass spectrum, to be 4,5-dimethylthiazole-N-oxide-S-oxide. This is the first reported metabolite which involves the oxidation of the two heterocyclic atoms in aromatic rings. The formation and thermal stability of the compound is ascribed to resonance stabilization.

Related Compounds

  • Titanous chloride

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