European Journal of Clinical Pharmacology 1993-01-01

Minor and clinically non-significant interaction between toloxatone and amitriptyline.

S Vandel, G Bertschy, M C Perault, M Sandoz, S Bouquet, R Chakroun, S Guibert, B Vandel

Index: Eur. J. Clin. Pharmacol. 44(1) , 97-9, (1993)

Full Text: HTML

Abstract

The possibility of a pharmacokinetic interaction between amitriptyline and toloxatone (a new MAOI-A) has been studied in 17 depressed in-patients. Amitriptyline and its demethylated and hydroxylated metabolites in blood and urine were measured at steady state after the administration of amitriptyline with and without toloxatone in steady state. The metabolic status of patients was determined using the dextromethorphan phenotyping test. There was only a minor pharmacokinetic interaction between amitriptyline (AMT) and toloxatone, with a small increase in the AMT/NT (nortriptyline) plasma ratio: 0.68 before and 0.78 after toloxatone. The urinary excretion and plasma levels of AMT and its metabolites were not affected by the co-therapy. Three of the patients were poor metabolisers, but this did not predict the magnitude of the drug interaction. The interaction does not justify plasma level monitoring of amitriptyline as the change in pharmacokinetics was so small.

Related Compounds

  • Toloxatone

Related Articles:

5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO).

2014-01-01

[Drug Test. Anal. 6(7-8) , 607-13, (2014)]

Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells.

2015-05-01

[J. Pharmacol. Exp. Ther. 356 , 483-92, (2016)]

A double-blind comparison of moclobemide and toloxatone in out-patients presenting a major depressive disorder.

1992-01-01

[Psychopharmacology 106 Suppl , S118-9, (1992)]

Effect of acute ethanol administration on toloxatone pharmacokinetics in rabbits.

1999-05-01

[Alcohol. Clin. Exp. Res. 23(5) , 885-90, (1999)]

The deamination of noradrenaline and 5-hydroxytryptamine by rat brain and heart monoamine oxidase and their inhibition by cimoxatone, toloxatone and MD 770222.

1983-08-01

[Naunyn Schmiedebergs Arch. Pharmacol. 323(4) , 315-20, (1983)]

More Articles...