Synthesis of antagonists of muscarinic (M 3) receptors

KJ Broadley, RH Davies, C Escargueil…

Index: Broadley, Kenneth J.; Davies, Robin H.; Escargueil, Christine; Lee, Alan T.L.; Penson, Peter; Thomas, Eric J. Collection of Czechoslovak Chemical Communications, 2011 , vol. 76, # 7 p. 781 - 801

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Abstract

Abstract Several α-hydroxyamides with (2, 6-dialkoxyphenoxy) methyl substituents have been prepared and their activities as antagonists of the M 3 muscarinic receptor in guinea pig ileum have been evaluated. N-{1-[(Phenyl) methyl] piperidin-4-yl}-2-{2-[(2, 6- dimethoxyphenoxy)-methyl] phenyl}-2-hydroxypropanamide and N-(1-[{6-amino-4-[(1- propylpiperidin-4-yl) methyl] pyridin-2-yl} methyl] piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2 ...