Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest

…, X Bu, A Eleftheriou, A Parmar, C Hayek…

Index: Wakelin, Laurence P. G.; Bu, Xianyong; Eleftheriou, Alexandra; Parmar, Alpesh; Hayek, Charbel; Stewart, Bernard W. Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5790 - 5802

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Citation Number: 57

Abstract

We have synthesized a series of bis (9-aminoacridine-4-carboxamides) linked via the 9- position with neutral flexible alkyl chains, charged flexible polyamine chains, and a semirigid charged piperazine-containing chain. The carboxamide side chains comprise N, N- dimethylaminoethyl and ethylmorpholino groups. The compounds are designed to bisintercalate into DNA by a threading mode, in which the side chains are intended to form ...