High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.

S Yoshida, K Urakami, M Kito, S Takeshima, S Hirose

Index: J. Chromatogr. A. 530(1) , 57-64, (1990)

Full Text: HTML

Abstract

7-(Diethylamino)-3-[4-[iodoacetyl)amino)phenyl]-4-methylcoumarin (DCIA) and 4-(bromomethyl)-7-methoxycoumarin have been evaluated as fluoropyrimidine-derivatizing agents to be detected using peroxyoxalate chemiluminescence with high-performance liquid chromatography. The derivatization procedure required only one step. No chemiluminescence was observed from the bromo derivatives, and the detection limits of fluoropyrimidine compounds derivatized with the iodo compound and detected with peroxyoxalate chemiluminescence were in the low femtomole range.

Related Compounds

  • 4-(Bromomethyl)-7-...
  • 7-Diethylamino-3-[...

Related Articles:

Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer.

2014-01-01

[BMC Cancer 14 , 887, (2014)]

Characterization of adipose tissue-derived stromal vascular fraction for clinical application to cartilage regeneration.

2015-02-01

[In Vitro Cell. Dev. Biol. Anim. 51(2) , 142-50, (2015)]

Effect of codon adaptation on codon-level and gene-level translation efficiency in vivo.

2014-01-01

[BMC Genomics 15 , 1115, (2014)]

Exercise training, creatine supplementation, and bone health in ovariectomized rats.

2015-04-01

[Osteoporos. Int. 26(4) , 1395-404, (2015)]

Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis.

2015-02-15

[Hum. Mol. Genet. 24(4) , 1106-18, (2015)]

More Articles...