Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3

JJ Chen, KD Thakur, MP Clark, SK Laughlin…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 21 p. 5633 - 5638

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Citation Number: 32

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Screening the internal kinase compound collections and hit follow-up resulted in 1,4-disubstituted pyrimidines, represented by structure 2. Further chemistry efforts pursuing this lead produced a novel class of potent and selective ...