Antibacterial single-bead screening

S Lebreton, N Newcombe, M Bradley

Index: Lebreton, Sylvain; Newcombe, Nicholas; Bradley, Mark Tetrahedron, 2003 , vol. 59, # 51 p. 10213 - 10222

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Citation Number: 41

Abstract

Triazine based antibiotics were prepared by the attachment of cyanuric chloride onto a Marshall-type safety catch linker, followed by successive aromatic nucleophilic substitutions, linker activation and nucleophilic cleavage. High-loading dendrimer beads allowed the release of sufficient amount of compound from a single bead to give clear inhibition.