Prikladnaia Biokhimiia i Mikrobiologiia 2010-01-01

[Photobiochemistry of folates: a photochemical reduction of folic acid].

Iu L Vechtomova, T A Telegina, M P Kolesnikov, M S Kritskiĭ

Index: Prikl. Biokhim. Mikrobiol. 46(3) , 372-8, (2010)

Full Text: HTML

Abstract

Exposure of deaerated folic acid solutions containing an electron donor to UV radiation (310-390 nm, I = 0.4 W m(-2)) induced formation of dihydrofolic acid (DHFA), a photoexcitation which gave tetrahydrofolic acid (THFA). Only DHFA was formed in the presence of EDTA (E'o = +0.40 V), while the presence of stronger reductants-NADH (E'o = -0.32 V) and boron hydride (E'o = -0.48 V)-induced photoreduction to THFA. It was demonstrated that UV radiation had no effect on the THFA formylation, giving the coenzyme 5,10-methenyltetrahydrofolic acid and its transformation into another coenzyme, 5-formyltetrahydrofolic acid.

Related Compounds

  • L-5,6,7,8-Tetrahy...
  • Dihydrofolic acid

Related Articles:

Quantitation of 5-Methyltetrahydrofolic Acid in Dried Blood Spots and Dried Plasma Spots by Stable Isotope Dilution Assays.

2015-01-01

[PLoS ONE 10 , e0143639, (2015)]

Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis.

2015-02-01

[Exp. Parasitol. 149 , 16-23, (2015)]

Folate levels measured by LC-MS/MS in patients with colorectal cancer treated with different leucovorin dosages.

2014-12-01

[Cancer Chemother. Pharmacol. 74(6) , 1167-74, (2014)]

Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.

2014-07-11

[Biochem. Biophys. Res. Commun. 449(4) , 392-8, (2014)]

A pharmacokinetic and pharmacodynamic investigation of Modufolin® compared to Isovorin® after single dose intravenous administration to patients with colon cancer: a randomized study.

2015-01-01

[Cancer Chemother. Pharmacol. 75(1) , 37-47, (2015)]

More Articles...