Fulvestrant: From the laboratory to commercial-scale manufacture

EJ Brazier, PJ Hogan, CW Leung…

Index: Organic Process Research and Development, , vol. 14, # 3 p. 544 - 552

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Citation Number: 14

Abstract

... Organic Process Research & Development. ... This procedure prevented formation of the bromo-impurities but led to a slightly elevated level of the Δ6,7-impurity 29. ... Various methods for removal of used copper reagent at the end of the process were investigated. ...