Natural Product Research 2006-08-01

Hemisynthesis of new labdane derivatives from (-)-sclareol.

Abdel Waheb Fekih, Karima Gafsi, Letitia Ferreiro-Mederos, Gilles Hanquet

Index: Nat. Prod. Res. 20(10) , 887-95, (2006)

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Abstract

A straightforward and very simple access to different analogues of (+)-subersic acid 7, the unnatural enantiomer (compounds 12) from naturally occurring (-)-sclareol 1 is described. We also report new conditions for the preparation of keto-intermediate 8 using maleic acid and describe hemiketal 11 as the new intermediate of degradative oxidation of 1.

Related Compounds

  • Sclareol

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