Chemistry & Biodiversity 2006-01-01

Structure elucidation and antibacterial activity of new fungal metabolites of sclareol.

M Iqbal Choudhary, Zafar Ali Siddiqui, Samreen Hussain

Index: Chem. Biodivers. 3(1) , 54-61, (2006)

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Abstract

The transformation of the antibacterial diterpene sclareol (1) by two different fungal strains was investigated (Scheme). In the presence of Rhizopus stolonifer, (3beta)-3-hydroxysclareol (2), 18-hydroxysclareol (3), (6alpha)-6,18-dihydroxysclareol (4), and (11S)-11,18-dihydroxysclareol (5) were formed. Fermentation of 1 with Fusarium lini afforded (1beta)-1-hydroxysclareol (6) and (12S)-12-hydroxysclareol (7). Compounds 4-7 were identified as new compounds, and some of them were active against Bacillus subtilis (Table 3).

Related Compounds

  • Sclareol

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