Synthesis of new potential anticancer agents based on 4-thiazolidinone and oleanane scaffolds

D Kaminskyy, B Bednarczyk-Cwynar…

Index: Kaminskyy, Danylo; Bednarczyk-Cwynar, Barbara; Vasylenko, Olexandr; Kazakova, Oxana; Zimenkovsky, Borys; Zaprutko, Lucjusz; Lesyk, Roman Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3568 - 3580

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Citation Number: 21

Abstract

Abstract The synthesis and evaluation of the anticancer activity of new acylated oximes derivatives of oleanolic acid with 4-thiazolidinone-3 (5)-carboxylic acid moieties were described. Newly synthesized compounds were elucidated on the basis of elemental analyses and spectral data (IR, 1 H, and 13 C NMR). Anticancer activity of the tested compounds has been evaluated in vitro at National Cancer Institute (NCI) in which some ...

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