Cyclization of the Semicarbazones to 1, 3, 4-Oxadiazole Derivatives Using Ceric Ammonium Nitrate as Oxidant

H Vahedi, J Lari, A Bavand…

Index: Vahedi; Lari; Bavand; Ameri Asian Journal of Chemistry, 2012 , vol. 24, # 1 p. 288 - 290

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Abstract

Abstract Cyclization of the semicarbazones to 1, 3, 4-oxadiazole using ceric ammonium nitrate as oxidant was studied. 2-Imino-1, 3, 4-oxadiazolines can be produced from semicarbazones, which undergo thermolysis to amides. Benzoic acid benzylidene hydrazide can also be cyclized to 2-methoxy-2-phenyl-1, 3, 4-oxadiazole in the presence of ceric ammonium nitrate and methanol.