Tricyclic pharmacophore-based molecules as novel integrin α v β 3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting α v β 3/α IIb β 3 dual …

D Kubota, M Ishikawa, M Yamamoto…

Index: Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2089 - 2108

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Citation Number: 25

Abstract

... Bioorganic & Medicinal Chemistry. ... When we started our integrin research program, three major pharmaceutical companies had already reported their original α v β 3 antagonists, including ... Thus, we attempted to enhance the α v β 3 -antagonistic activity by chemical modification. ...

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

[Journal of Medicinal Chemistry, , vol. 49, # 3 p. 1165 - 1181]

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

[Journal of Medicinal Chemistry, , vol. 49, # 3 p. 1165 - 1181]

Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2, 3-dihydroisoindolin-1-one …

[Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661]

Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2, 3-dihydroisoindolin-1-one …

[Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661]

Tricyclic pharmacophore-based molecules as novel integrin α v β 3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting α v β 3/α IIb β 3 dual …

Abstract

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