Synthesis and antitumour evaluation of peptidyl-like derivatives containing the 1, 3-benzodioxole system

DR de Magalhães Moreira, ACL Leite…

Index: Moreira, Diogo Rodrigo de Magalhaes; Lima Leite, Ana Cristina; Pinheiro Ferreira, Paulo Michel; da Costa, Patricia Marcal; Costa Lotufo, Leticia Veras; de Moraes, Manoel Odorico; Brondani, Dalci Jose; do O Pessoa, Claudia European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 351 - 357

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Citation Number: 37

Abstract

In the scope of a research program aiming at the synthesis and pharmacological evaluation of novel possible antitumour prototype compounds, we described in this paper the synthesis of peptidyl-like derivatives containing the 1, 3-benzodioxole system. The proliferation inhibitors tested against tumour cell lines identified the derivatives tyrosine (4f) and lysine (4g) as the most active among them, presenting IC50 values in micromolar range and are ...