Synthesis and Characterization of Impurity B of S-(+)-Clopidogrel Bisulfate: An Antiplatelet

KT Reddy, KS Kumar, G Omprakash…

Index: Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash; Dubey Synthetic Communications, 2013 , vol. 43, # 10 p. 1387 - 1396

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Abstract

S-(+)-Clopidogrel bisulfate [(S-(+)-methyl 2-(2-chlorophenyl)-2-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-yl)acetate bisulfate)] is a platelet aggregation inhibitor drug. S-(+)-Clopidogrel bisulfate is prepared by different synthetic approaches in the literature. In almost all the approaches the major impurities known in the literature (A, B, and C) are also listed in the US pharmacopoeia. The control of these pharmaceutical impurities is currently a critical issue ...

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