New solid support for the synthesis of 3'-oligonucleotide conjugates through glyoxylic oxime bond formation

N Spinelli, OP Edupuganti, E Defrancq, P Dumy

Index: Organic Letters, , vol. 9, # 2 p. 219 - 222

Full Text: HTML

Citation Number: 19

Abstract

... Volume: Page: ... Organic Letters. ... 23 Purified conjugates 9a and 12a were incubated (10 - 5 M) in phosphate buffer solutions with pH values adjusted to 4, 7, and 9. The percentage of hydrolysis of the two linkages was estimated by RP-HPLC analysis after 24, 48 ...