Application of Chemoselective Pancreatin Powder-Catalyzed Deacetylation Reaction in the Synthesis of Key Statin Side Chain Intermediate (4 R, 6 S)-4-(tert- …

V Troiani, J Cluzeau, Z Časar

Index: Palomo, Jose M.; Filice, Marco; Fernandez-Lafuente, Roberto; Terreni, Marco; Guisan, Jose M. Advanced Synthesis and Catalysis, 2007 , vol. 349, # 11-12 p. 1969 - 1976

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Citation Number: 12

Abstract

... deacetylation process of acetate 1 to alcohol 2 by the use of enzymatic catalysis in aqueous ... Figure 1. Retrosynthetic analysis of the synthesis of optically pure superstatins containing hept-6-enoic ... product was isolated in even lower yield (51%) than with a tin catalyst (66%),(6a ...

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