Organic Letters 2007-07-05

Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes.

Justin R Denton, Dinesh Sukumaran, Huw M L Davies

Index: Org. Lett. 9 , 2625, (2007)

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Abstract

The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh2(R-PTAD)4, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94%) and enantioselectivity (88->98%).

Related Compounds

  • 4-Methylbenzenesul...

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