Tetrahedron

Synthesis of 1, 4-dihydro-2-methyl-4-oxo-nicotinic acid: Ochiai's route failed

MG Ferlin, VB Di Marco, A Dean

Index: Ferlin, Maria Grazia; Di Marco, Valerio B.; Dean, Annalisa Tetrahedron, 2006 , vol. 62, # 26 p. 6222 - 6227

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Citation Number: 9

Abstract

The synthesis of 1, 4-dihydro-2-methyl-and 1, 4-dihydro-1, 2-dimethyl-4-oxo-nicotinic acids was accomplished following a route other than Ochiai's procedure, which yielded the isomer 1, 6-dihydro-2-methyl-6-oxo-nicotinic acid ethyl ester, and not the 4-oxo-derivative, as reported. Analytical data confirmed the identity of the two isomer oxo-nicotinic acids. UV–vis and potentiometric preliminary data showed that Al (III) does not form complexes with 1, 6- ...