Pyrrolidine-modified and 6-substituted analogs of nicotine: A structure—affinity investigation

…, W Fiedler, D Dumas, I Damaj, BR Martin…

Index: Dukat, M.; Fiedler, W.; Dumas, D.; Damaj, I.; Martin, B. R.; et al. European Journal of Medicinal Chemistry, 1996 , vol. 31, # 11 p. 875 - 888

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Citation Number: 64

Abstract

Because the structural requirements for the binding of nicotine to central nicotine receptors remain largely uninvestigated, we undertook a systematic investigation of pyrrolidine ring- opened analogs. This led to a subsequent investigation of related conformationally restricted derivatives of these analogs. The results are reported relative to the binding of several well- known and widely used nicotine receptor ligands. Although none of the ring-opened ...